Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Diabody-CH3) (BSDBC-H219)

Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-CD19 and anti-CD47 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can retarget macrophages to tumor cells. It is designed for the research of B cell lymphoma; Follicular lymphoma; Burkitt lymphoma; Leukemia therapy.

Datasheet INQUIRY

Specifications

Targets

CD19 & CD47

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

B cell lymphoma; Follicular lymphoma; Burkitt lymphoma; Leukemia

Targets

Target 1

CD19

Gene ID

930

UniProt ID

P15391

Alternative Names

CD19; CD19 molecule; Cluster of differentiation 19; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4

Target 2

CD47

Gene ID

961

UniProt ID

Q08722

Alternative Names

CD47; CD47 molecule; IAP; OA3; MER6; leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; antigenic surface determinant protein OA3; antigen identified by monoclonal antibody 1D8; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Diabody-CH3) (CAT#: BSDBC-H219)

Specifications

Targets

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