Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (F(ab')2-scFv2) (BABFV-042)

Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-CD19 specificity is fused to the C terminus of the anti-CD47 Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can retarget macrophages to tumor cells. It is designed for the research of B cell lymphoma; Follicular lymphoma; Burkitt lymphoma; Leukemia therapy.

Datasheet INQUIRY

Specifications

Targets

CD19 & CD47

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

B cell lymphoma; Follicular lymphoma; Burkitt lymphoma; Leukemia

Targets

Target 1

CD19

Gene ID

930

UniProt ID

P15391

Alternative Names

CD19; CD19 molecule; Cluster of differentiation 19; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4

Target 2

CD47

Gene ID

961

UniProt ID

Q08722

Alternative Names

CD47; CD47 molecule; IAP; OA3; MER6; leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; antigenic surface determinant protein OA3; antigen identified by monoclonal antibody 1D8; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (F(ab')2-scFv2) (CAT#: BABFV-042)

Specifications

Targets

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