Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Fab-scFv-Fc) (FABVC-053)

Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD22 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-saporin to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can be used in pretargeting system and deliver immunotoxin to tumor cells. It is designed for the research of Lymphoma therapy.

Datasheet INQUIRY

Specifications

Targets

CD22 & Saporin

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Pretargeting system for immunotoxin delivery

Related Disease

Lymphoma

Targets

Target 1

CD22

Gene ID

933

UniProt ID

P20273

Alternative Names

CD22; CD22 molecule; Cluster of differentiation 22; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2

Target 2

Saporin

Alternative Names

Saporin; Ribosome inactivating protein; RIP

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-053)

Specifications

Targets

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