Recombinant Anti-CD3 x Anti-VEGFR2 Bispecific Antibody (scFv-CH3) (BSFC-109)

Recombinant Anti-CD3 x Anti-VEGFR2 Bispecific Antibody (scFv-CH3) contains two chains. The anti-CD3 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-VEGFR2 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget T cells to tumor cells. It is designed for the research of Colorectal cancer (CRC); Non-small cell lung cancer (NSCLC); Glioblastoma therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & VEGFR2

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Colorectal cancer (CRC); Non-small cell lung cancer (NSCLC); Glioblastoma

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

VEGFR2

Gene ID

3791

UniProt ID

A0A024RD88

Alternative Names

FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; Kinase insert domain receptor; Fetal liver kinase 1; Kinase insert domain receptor, a type III receptor; KDR

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD3 x Anti-VEGFR2 Bispecific Antibody (scFv-CH3) (CAT#: BSFC-109)

Specifications

Targets

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