Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Minibody) (MiniB-121)

Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CD44 scFv fused to N-terminus of Knob-CH3 domain and the anti-CR3 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can recruit macrophages to tumor cells. It is designed for the research of Glioblastoma; Squamous cancer therapy.

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Specifications

Targets

CD44 & CR3

Type

Minibody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Glioblastoma; Squamous cancer

Targets

Target 1

CD44

Gene ID

960

UniProt ID

P16070

Alternative Names

CD44; CD44 antigen; ECMRIII; Extracellular matrix receptor III; HCAM; Homing cell adhesion molecule; Pgp-1; phagocytic glycoprotein-1; HUTCH-1; Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109

Target 2

CR3

Gene ID

719

UniProt ID

Q16581

Alternative Names

C3AR1; complement C3a receptor 1; AZ3B; C3AR; HNFAG09; CR3; Complement receptor type 3; CD11b/CD18; Mac-1; Macrophage antigen 1; αmβ2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Minibody) (CAT#: MiniB-121)

Specifications

Targets

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