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IL13 & IL4 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-H337 Recombinant Human Anti-IL13 x Anti-IL4 Bispecific Antibody (Tandem Diabody) Human IL13 IL4 Inquiry
T-BSDB-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Tandem Diabody) Human IL13 IL4 Inquiry
SCIGG-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (scIgG) Human Single chain IgGs IL13 IL4 Inquiry
SCIGG-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scIgG) Human Single chain IgGs IL13 IL4 Inquiry
FVTIG-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (scFv4-Ig) Human Appended IgGs IL13 IL4 Inquiry
FVTIG-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scFv4-Ig) Human Appended IgGs IL13 IL4 Inquiry
BSSG-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (scFv-IgG) Human Appended IgGs IL13 IL4 Inquiry
BSSG-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scFv-IgG) Human Appended IgGs IL13 IL4 Inquiry
IGLFV-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs IL13 IL4 Inquiry
IGLFV-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs IL13 IL4 Inquiry
BSGV-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL13 IL4 Inquiry
BSGV-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL13 IL4 Inquiry
BSDG-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (Fv-IgG) Human Appended IgGs IL13 IL4 Inquiry
BSDG-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Fv-IgG) Human Appended IgGs IL13 IL4 Inquiry
BABFV-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins IL13 IL4 Inquiry
BABFV-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins IL13 IL4 Inquiry
FABVC-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins IL13 IL4 Inquiry
FABVC-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins IL13 IL4 Inquiry
SCDBC-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments IL13 IL4 Inquiry
SCDBC-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments IL13 IL4 Inquiry
BSDBC-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments IL13 IL4 Inquiry
BSDBC-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments IL13 IL4 Inquiry
SCDBF-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL4 Inquiry
SCDBF-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL4 Inquiry
BSFVF-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL4 Inquiry
BSFVF-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL4 Inquiry
BSDBF-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL4 Inquiry
BSDBF-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL4 Inquiry
BSTF-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments IL13 IL4 Inquiry
BSTF-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments IL13 IL4 Inquiry
BSCFV-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments IL13 IL4 Inquiry
BSCFV-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments IL13 IL4 Inquiry
MNAB-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments IL13 IL4 Inquiry
MNAB-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments IL13 IL4 Inquiry
BSFC-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments IL13 IL4 Inquiry
BSFC-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments IL13 IL4 Inquiry
BSCC-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments IL13 IL4 Inquiry
BSCC-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments IL13 IL4 Inquiry
BIBD-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (Bibody) Human Bibody IL13 IL4 Inquiry
BIBD-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Bibody) Human Bibody IL13 IL4 Inquiry
FABFV-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL13 IL4 Inquiry
FABFV-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL13 IL4 Inquiry
MiniB-H338 Recombinant Human Anti-IL13 x Human Anti-IL4 Bispecific Antibody (Minibody) Human Minibody IL13 IL4 Inquiry
MiniB-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Minibody) Human Minibody IL13 IL4 Inquiry
SCDB-H337 Recombinant Human Anti-IL13 x Anti-IL4 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL13 IL4 Inquiry
FABIG-H337 Recombinant Human Anti-IL13 x Anti-IL4 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL13 IL4 Inquiry
TRIB-H339 Recombinant Human Anti-IL13 x Anti-IL4 Bispecific Antibody (Triple Body) Human Triple Body IL13 IL4 Inquiry
BSIG-H337 Human Anti-IL13 x Anti-IL4 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL13 IL4 Inquiry
CROSSAB-H337 Recombinant Human Anti-IL13 x Anti-IL4 Bispecific Antibody (CrossMab) Human CrossMab IL13 IL4 Inquiry
IGFV-H337 Recombinant Human Anti-IL13 x Anti-IL4 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL13 IL4 Inquiry
BSDB-H337 Recombinant Human Anti-IL13 x Anti-IL4 Bispecific Antibody (Diabody) Human Diabody IL13 IL4 Inquiry
BSFAB-H337 Recombinant Human Anti-IL13 x Anti-IL4 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL13 IL4 Inquiry
BSFV-H335 Recombinant Human Anti-IL13 x Anti-IL4 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL13 IL4 Inquiry
SCDB-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL13 IL4 Inquiry
FABIG-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL13 IL4 Inquiry
TRIB-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Triple Body) Human Triple Body IL13 IL4 Inquiry
BSIG-173 Anti-IL13 x Anti-IL4 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL13 IL4 Inquiry
CROSSAB-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (CrossMab) Human CrossMab IL13 IL4 Inquiry
IGFV-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL13 IL4 Inquiry
BSDB-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Diabody) Human Diabody IL13 IL4 Inquiry
BSFAB-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL13 IL4 Inquiry
BSFV-173 Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL13 IL4 Inquiry
BSDG-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Fv-IgG) Human Appended IgGs IL13 IL17 Inquiry
BSDG-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Fv-IgG) Human Appended IgGs IL13 IL17 Inquiry
BABFV-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins IL13 IL17 Inquiry
BABFV-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins IL13 IL17 Inquiry
FABVC-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins IL13 IL17 Inquiry
FABVC-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins IL13 IL17 Inquiry
SCDBC-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments IL13 IL17 Inquiry
SCDBC-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments IL13 IL17 Inquiry
BSDBC-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments IL13 IL17 Inquiry
BSDBC-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments IL13 IL17 Inquiry
SCDBF-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL17 Inquiry
SCDBF-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL17 Inquiry
BSFVF-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL17 Inquiry
BSFVF-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL17 Inquiry
BSDBF-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL17 Inquiry
BSDBF-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments IL13 IL17 Inquiry
BSTF-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments IL13 IL17 Inquiry
BSTF-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments IL13 IL17 Inquiry
BSCFV-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments IL13 IL17 Inquiry
BSCFV-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments IL13 IL17 Inquiry
MNAB-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments IL13 IL17 Inquiry
MNAB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments IL13 IL17 Inquiry
BSFC-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments IL13 IL17 Inquiry
BSFC-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments IL13 IL17 Inquiry
BSCC-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments IL13 IL17 Inquiry
BSCC-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments IL13 IL17 Inquiry
BIBD-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Bibody) Human Bibody IL13 IL17 Inquiry
BIBD-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Bibody) Human Bibody IL13 IL17 Inquiry
FABFV-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL13 IL17 Inquiry
FABFV-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL13 IL17 Inquiry
MiniB-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Minibody) Human Minibody IL13 IL17 Inquiry
MiniB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Minibody) Human Minibody IL13 IL17 Inquiry
SCDB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL13 IL17 Inquiry
FABIG-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL13 IL17 Inquiry
TRIB-H338 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Triple Body) Human Triple Body IL13 IL17 Inquiry
BSIG-H336 Human Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL13 IL17 Inquiry
CROSSAB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (CrossMab) Human CrossMab IL13 IL17 Inquiry
IGFV-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL13 IL17 Inquiry
BSDB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Diabody) Human Diabody IL13 IL17 Inquiry
BSFAB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL13 IL17 Inquiry
BSFV-H334 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL13 IL17 Inquiry
SCDB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL13 IL17 Inquiry
FABIG-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL13 IL17 Inquiry
TRIB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Triple Body) Human Triple Body IL13 IL17 Inquiry
BSIG-172 Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL13 IL17 Inquiry
CROSSAB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (CrossMab) Human CrossMab IL13 IL17 Inquiry
IGFV-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL13 IL17 Inquiry
BSDB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Diabody) Human Diabody IL13 IL17 Inquiry
BSFAB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL13 IL17 Inquiry
BSFV-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL13 IL17 Inquiry

Background

Interleukin (IL)-4 and IL-13 contain 25% amino acid similarity and have overlapping functions. They belong to the T helper (Th) 2 cytokine family. They share a single receptor, known as a type II receptor. This receptor is a heterodimer composed of one component of the IL-4 receptor (IL-4R) and one subunit of the IL-13 receptor (IL-13R). However, due to variations in IL-4R and IL-13R distributions and concentrations, IL-4 operates largely in hematopoietic/immune cells, such as B cells, mast cells, basophils, and macrophages. Whereas IL-13 acts primarily in non-hematopoietic/immune cells, such as epithelial cells, fibroblasts, and smooth muscle cells, as shown in Fig.1. The bi-target antibody that targets both IL-13 and IL-4 have the potential to treat several immune-related disorders, particularly those characterized by overactive immune responses or autoimmunity.

Fig.1 The IL-4 & IL-13 effects on hematopoietic/non-hematopoietic cells.(Matsunaga,et al, 2020) Fig.1 The actions of IL-4 and IL-13 on various hematopoietic/immune and non-hematopoietic/immune cells.1

Reference

  1. Matsunaga, Kazuto, et al. "Dupilumab: Basic aspects and applications to allergic diseases." Allergology International 69.2 (2020): 187-196.
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