Creative Biolabs is a world-leading service provider of application-specific antibody development. Here, we introduce our in vitro diagnostic (IVD) antibody development and immunoassay development services targeting the ANGPTL2 marker. We are confident that our commitment to science and research will enable us to offer you the best products and services.
Angiopoietin-Related Protein 2 (ANGPTL2)
ANGPTL2 is a protein encoded by the ANGPTL2 gene in humans. It maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue remodeling. However, an excess of ANGPTL2 activation induced by long-term stress promotes the breakdown of tissue homeostasis caused by chronic inflammation, promoting the development of metabolic diseases. ANGPTL2 also has a role in tissue repair, angiogenesis, atherosclerotic disease, obesity and finally in cancerogenesis. Angiopoietin belongs to the vascular endothelial growth factor family and is the only known growth factor that is primarily used in the vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 are involved in the formation of blood vessels. Besides, the ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietin and functions as an endothelial cell through autocrine or paracrine action.
Fig.1 Structure of ANGPTL2.1
ANGPTL2 Marker of Diabetes
Cardiovascular disease (CVD) is the main determinant of outcomes in patients with type 2 diabetes mellitus according to mortality and morbidity. Type 2 diabetes mellitus is connected with a twofold elevated risk of mortality and a threefold elevated risk of coronary artery disease, when compared to patients without diabetes. A high serum ANGPTL2 concentration is an independent risk predictor for developing diabetes and is correlated with insulin resistance and atherosclerosis. Recently, a study has demonstrated that serum ANGPTL2 concentrations were highly and independently associated with death and MACE in patients with type 2 diabetes mellitus. Meanwhile, they have shown that ANGPTL2 may be a potential biomarker for increasing risk stratification in type 2 diabetes mellitus patients. It has also been indicated by other researches that ANGPTL2 levels were increased in type 2 diabetes patients with an independent connection between raising ANGPTL2 levels and improving levels of albuminuria.
ANGPTL2 Marker of Gastric Cancer
Gastric cancer (GC) is one of the most usual malignancies and ranks second in global cancer involved mortality. Early determination is the most hopeful method in promoting long-term survival of GC patients. However, ~70% of GC patients are initially diagnosed at late stages with locally advanced or metastatic disease. Now, it is widely accepted that chronic inflammation serves an essential role in cancer progressions, such as carcinogenesis and tumor development. Studies have shown that the ANGPTL2 concentration in gastric cancer patients was notably increased compared to healthy controls. Besides, based on the ROC analysis, ANGPTL2 displayed greater diagnostic capacity than the classic biomarkers (CRP, CEA and CA19-9). These results indicated that ANGPTL2 was a promising clinically relevant biomarker for gastric cancer. In addition, it has also demonstrated that serum ANGPTL2 levels in breast cancer patients may be a possible marker of breast cancer metastasis.
Fig.2 Regulation of ICI-associated autoimmune myocarditis by cardiac fibroblast-derived ANGPTL2.2
ANGPTL2 Marker of Esophageal Cancer
ANGPTL2 mediates chronic inflammation. The increased ANGPTL2 expression has also been detected in tumor cells in hypoxic regions and undernourishment, suggesting that the tumor microenvironment induces ANGPTL2 expression. Moreover, Tumor cell-derived ANGPTL2 promotes tumor invasion and angiogenesis. Overexpression of ANGPTL2 in tumor cells is associated with tumor progression and has been recognized in esophageal cancer. On the other hand, ANGPTL2 expression in isolated tumor cells is highly associated with metastasis to lymph nodes or distant organs due to increased angiogenesis in the tumor environment and increased tumor cell invasion and migration through epithelial-mesenchymal transition. Thus, cancer cell- and/or tumor microenvironment-derived ANGPTL2 is considered to be a critical factor in inflammation-induced carcinogenesis and cancer progression. In addition, ANGPTLs have an N-terminal signaling sequence for protein secretion, which has been detected in systemic circulation under obesity-induced inflammation, suggesting that serum ANGPTL2 levels may be a useful diagnostic and predictive biomarkers in cancer patients.
IVD Antibody Development Services Targeting the ANGPTL2 Marker
IVD antibodies have been commonly used in immunodiagnostic kits for disease diagnosis and prognosis. Creative Biolabs has built a versatile IVD platform to provide custom biomarker-specific IVD antibody development services to global clients. Along with over a decade of rich experience in providing excellent custom services for IVD antibody discovery, our services can totally meet your special requirements.
In addition, Creative Biolabs provides one-stop diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, validation, and production. If you are interested in our services, please do not hesitate to contact us for more details.
References
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