Creative Biolabs is one of the leading custom antibody generation and development providers. We specialize in the generation of antibodies against a wide range of targets for R&D, diagnostic, and therapeutic applications. Currently, we have launched a series of in vitro diagnostic (IVD) antibody & immunoassay development services targeting numerous diagnostic biomarkers of human diseases. Here, we focus on the lactate dehydrogenase (LDH), a tumor/cancer biomarker.
LDH is an enzyme found in nearly all living cells (animals, plants, and prokaryotes). LDH catalyzes the conversion of lactate to pyruvic acid and back, as it converts NAD+ to NADH and back. A dehydrogenase is an enzyme that transfers a hydride from one molecule to another. LDH is expressed extensively in body tissues, such as blood cells and heart muscle. Because it is released during tissue damage, it is a marker of common injuries and diseases such as heart failure. LDH is a protein that normally appears throughout the body in small amounts. Many cancers can raise LDH levels, so LDH may be used as a tumor marker. Measuring LDH levels can be helpful in monitoring the treatment of cancer.
Fig.1 LDH activity.1
Serum LDH is a key biomarker in many types of cancer as baseline LDH levels become elevated following tissue injury or during disease, and high serum LDH levels are frequently found in human malignancies, including non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and Ewing's sarcoma of the bone. Besides, elevated levels of serum LDH are prognostic biomarkers for poor survival in different cancers, including operable NSCLC, multiple myeloma, lymphoma, prostate cancer, and hematological malignancies. Besides, they are indicators of in-hospital mortality for patients with advanced cancer, although not for patients in the terminal stages. Also, LDH has been shown to be a predictive biomarker of outcome and therapeutic response in cancer patients through molecular agents and it has been associated with tumor resistance to therapy.
Antibodies are core elements for immunoassays to detect and quantify analytes of interest in different samples such as the serum, urine, tissue preparations, and so on. At Creative Biolabs, we offer a full range of antibody development, antigen & antibody conjugation, and IVD immunoassay development services to clients across the globe. Our expertise lies in different stages of the immunoassay development process and different immunoassay technology platforms, including ELISAs, lateral flow immunochromatographic assays, immuno-PCR, etc. For information, please click the following links:
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