To Know Our In Vitro Diagnostics

In vitro diagnostic (IVD) products, including regents, kits, antibodies, calibrations, etc., provide rapid, convenient, and accurate diagnosis and monitoring for a wide range of human diseases, of which IVD antibodies are decisive components of different antibody-based kits or diagnostic assays. Obtaining antibodies with high affinity and specificity to the biological markers is the first and most important step when developing reliable immunodiagnostic kits or assays. The emergence of new technologies has not only improved the sensitivity, accuracy, and reliability of in vitro diagnostics but also greatly reduced the costs and time of diagnostics.

To excavate IVD products with higher quality and advance the development of in vitro diagnostics, Creative Biolabs offers customized discovery and development services of diagnostic antibodies for a variety of disease areas including, but not limited to, autoimmune diseases, cancer, infectious diseases, and cardiovascular diseases. Our powerful technology platform and experienced scientists will do their utmost to make sure you each process from the preparation of antigens to the production of custom antibodies.

To Know Our Main IVD Antibody Development Services

The main IVD antibody development services include:

Fig.1 Monoclonals. (From Wikipedia: By Adenosine - Own work, https://commons.wikimedia.org/wiki/File:Monoclonals.png.)

Monoclonal Antibody Development

Monoclonal antibodies have always been the protagonists of basic research, therapeutics, and diagnostics. With decades of experience, Creative Biolabs offers one-stop monoclonal antibody development services using a variety of methods, such as hybridomas, phage display technologies, recombinant expression, and single B-cell technology. Our monoclonal antibody development service is flexible, cost-effective, and time-saving, and has won a good reputation during these decades.

Fig.2 Polyclonals. (Wendy, 2019)

Polyclonal Antibody Development

Polyclonal antibodies recognize multiple epitopes on an antigen and have relatively lower cost and shorter lead-time in preparation. Creative Biolabs offers high-quality polyclonal antibody development services, covering a variety of species, including rabbits, goats, chickens, and more. And each polyclonal antibody development project is tailored to your specific needs.

Fig.3 Recombinant antibody development. (Creative Biolabs Authorized)

Recombinant Antibody Development

Creative Biolabs provides recombination antibody services covering from gene synthesis to antibody purification. Related antibody engineering services, such as antibody affinity maturation, antibody chimerization, antibody humanization, isotype switching, antibody reformatting, etc., are also within our capabilities.

Fig.4 Antibody pairs development. (Ziraldo, et al., 2019)

Antibody Pairs Development

Antibody pairs, consisting of capturing antibodies and detecting antibodies, are two different antibodies generated against different epitopes or binding regions on one target. The matched antibody pairs are usually applied for antigen or biomarker detection and enzyme-linked immunosorbent assays. In addition to a wide range of off-the-shelf antibody pair sets, Creative Biolabs provides development services for antibody pairs in different formats, including mAb-mAb, mAb-pAb, and pAb-pAb.

To Know Our IVD Antibody Development Process

The IVD antibody development services provided by Creative Biolabs can be customized in one stop or customized separately, the main steps include the following:

  1. Immunogen Design
    Select the best antigen sequence and the most suitable protein expression system to express the purified antigen.
  2. Animal Immunization
    To meet the client's particular host requirements, antibodies may be produced in a mouse, rat, rabbit, or other type of animal.
  3. Antibody Development
    Hybridoma, single B cell, and phage display techniques can all be used for the development of customized monoclonal or polyclonal antibodies.
  4. Antibody Screening
    Select appropriate screening tests to obtain candidate antibodies.
  5. Antibody Purification
    Isolating and purifying antibodies by salting-out, gel column chromatography, ion exchanger chromatography, and immunoaffinity chromatography.
  6. Antibody Optimization & Modification
    We provide antibody optimization and antibody modification services according to customer's requirements.
  7. Functional Assay
    Verify the performance of antibodies by Western blot, ELISA, Immunohistochemistry, flow cytometer, etc.
  8. Antibody Production
    Small-scale or large-scale production of antibodies.

To Know Our IVD Antibody Development Advantages

  • Custom IVD antibodies development against a wide range of disease biomarkers
  • Different antibody technologies are available based on your needs
  • Extensive experience in ancillary techniques and services such as antibody purification and characterization
  • Fully customizable experimental design to meet customers' needs

IVD antibodies are the most often used and essential elements of many diagnostic assays. Creative Biolabs is very proud to provide our clients with IVD antibody development services due to our extensive experience and professional Research & Development team. In order to work side-by-side with you to develop the exact antibodies you need, please contact us for more information.

References

  1. From Wikipedia: By Adenosine - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/wiki/File:Monoclonals.png.
  2. Keenleyside, Wendy. "Microbiology." (2019).
  3. Ziraldo, Gaia, et al. "A human-derived monoclonal antibody targeting extracellular connexin domain selectively modulates hemichannel function." Frontiers in physiology 10 (2019): 392.

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