Proper in vitro models are prerequisites for effective in vitro pharmacodynamic and pharmacokinetic studies. Therefore, before conducting an in vitro evaluation of a drug, it is first necessary to select and construct a suitable model to be able to relatively realistically reflect various reactions of the drug in the human body. Creative Biolabs has an excellent one-stop drug development platform where we can provide a wide range of drug discovery services, as well as a wide range of high quality and advanced in vitro models and in vitro evaluation services of drugs. And the 3D cell model is the outstanding representative of our high-quality in vitro model.
Physiological activities such as cell proliferation, differentiation and metabolism are affected by the microenvironment. Most of the current cell biology research is still carried out in two-dimensional planar culture. In planar culture, the growth mode of cells differs greatly from the stereo environment in the body. As a result, cell morphology, differentiation, cell-matrix interactions, and cell-to-cell interactions are significantly different from those of cells in physiological conditions in vivo. The physiological indexes of cells cultured in 2D and 3D environments are significantly different. For example, primary mouse mammary luminal epithelial cells proliferated in 3D basement membrane matrix require a longer time than in 2D culture environment. In addition, sometimes the effect of the drug on cells cultured in 2D is opposite to that on 3D cells. In this case, 3D culture can be designed to simulate the physiological environment in the body, so that the cells are closer to the actual physiological environment of the body in physiological behavior. For this reason, drug developers are increasingly inclined to use 3D cultured cells to conduct experiments and research. This change not only allows developers to get rid of the constraints of ethical 3Rs on animal experiments to a considerable extent but also helps researchers shorten the development cycle, increase the credibility of the results, and save costs.
A key feature of the in vitro 3D model is its ability to mimic specific cellular behavior in vivo, enabling accurate prediction of tissue development and morphogenesis, and cell differentiation. Most importantly, it is able to reflect the genotype and/or phenotype response to the compound in drug and toxicity screening assays. Therefore, currently, 3D cell models can be used to study stem cell differentiation and organogenesis, to study cancer and tumor cell biology, as well as for drug discovery and in vitro pharmacodynamics and pharmacokinetic studies of drugs.
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