ADA Labeling Services

As a long-term pioneer as well as market leader in the field of anti-drug antibody development, Creative Biolabs has successfully established and commercialized a wide spectrum of assays to illustrate the potential immunogenicity of biological drugs. Particularly, we offer unique ADA labeling service for worldwide customers.

Importance of ADA Labeling

Biological drugs often elicit unwanted immune response that produces non-neutralizing and/or neutralizing anti-drug antibodies (ADAs), which may impact drug pharmacokinetics, clinical efficacy, and patient safety. It is critical to evaluate the potential immunogenicity risk of biotherapeutics in producing neutralizing and non-neutralizing anti-drug antibodies. During the past years, numerous different assay formats have been used to detect and quantify ADAs, including ELISA, radioimmunoassay, surface plasmon resonance, and electrochemiluminescence-based technologies. In these assays, the drug is labeled with different labels as detection reagent, and any antidrug antibodies present in a sample will form a bridge between the two labeled molecules.

Fig.1 Scheme of an antibody modification with sortase.^{1, 2}

ADA Labeling Services Provided by Creative Biolabs

Based on years of experience and advanced technology platform, Creative Biolabs is able to provide numerous assay formats for ADA immunogenicity assessment. With the help of multiple advanced instruments and devices, the intensity of the detectable label can be measured and analyzed by our professional scientists. In order to meet the specific meet of every client's requirements, we offer comprehensive ADA labeling services. The labels we often use are listed as below, including but not limited to:

• Hapten (e.g. digoxigenin, biotin)
• Enzymes, such as alkaline phosphatase (AP), beta-galactosidase, horseradish peroxidase (HRP), soybean peroxidase (SBP), urease, beta-lactamase, and glucose oxidase
• Electrochemiluminescent label
• Fluorescence label (e.g. FITC)
• Radioisotopes

Features of Our Services

• Abundant experience: deep knowledge in multiple immunoassays
• Flexible options for labeled methods
• High-quality services: well-characterized data interpretation service with specialized technical support
• Best after-sale services: short duration with competitive price

Aided by our professional technical team and cutting-edge technology platform, Creative Biolabs is confident in promoting the development of global customers' programs. Except for ADA labeling service, we also provide versatile immunogenicity assessment services for global customers, such as ADA screening assays and ADA confirmatory assays. If you are interested in learning more about our ADA service, please feel free to contact us and get exclusive technical support services. Our project manager will get in touch with you as soon as possible and help you design an appropriate labeling method for your specific requirements.

References

1. Falck, Georg, and Kristian M. Müller. "Enzyme-based labeling strategies for antibody–drug conjugates and antibody mimetics." Antibodies 7.1 (2018): 4.
2. Under Open Access license CC BY 4.0, without modification.

For Research Use Only.