During the past years, fungus infection has appeared in an increased mortality and morbidity. Antifungal drug discovery has raised attention across the world. As a leading company in the field of drug discovery industry, Creative Biolabs has successfully established advanced technology platforms which enable to provide numerous target exploiting services. Now, we are happy to introduce our high-quality antifungal drug discovery services for the treatment of fungus infection caused by Aspergillus Flavus (A. Flavus).
Introduction of A. Flavus
A. Flavus is an asexual species that belongs to section Flavi which contains the major economically important aflatoxin-producing fungi A. flavus and A. parasiticus. As the second leading cause of invasive and non-invasive aspergillosis, it only produces asexual spores, conidia, and the overwintering asexual fruiting bodies, sclerotia. Importantly, A. Flavus is a pathogen of plants, animals, and insects, causes storage rots in numerous crops, and it produces the highly regulated mycotoxin, aflatoxin B1. What’s more, aflatoxin could cause aflatoxicosis, resulting from inhaling or ingesting high levels of aflatoxin-contaminated food and feed.
Pathogenesis of A. Flavus
In the past, Aspergillus species have become increasingly important because immunosuppressed people are very susceptible to infection by these fungi. Generally, A. Flavus occurs as a saprophyte in soils worldwide and causes animal and human diseases either through consumption of contaminated feed (causing aflatoxicosis and/or liver cancer) or through invasive growth (causing aspergillosis). In addition, A. Flavus is also an allergen causing allergic bronchopulmonary aspergillosis. Studies have shown that most human infections arise through inhalation of fungal spores. Farmers infected from breathing in spores from contaminated foods and feeds have also been reported. Furthermore, allergic responses develop after repeated exposure to fungal spores, resulting in asthma, extrinsic alveolitis, or allergic bronchopulmonary aspergillosis.
Antifungal Drugs against A. Flavus
There are several drugs have been developed for the treatment of aspergillosis. However, failures of these drugs in cases of aspergillosis have already been reported. Therefore, it is urgent to develop more antifungal drugs for the treatment of A. Flavus infections.
Features of our Services
Based on years of experience and professional scientists, Creative Biolabs has successfully offered multiple potential targets exploiting services for worldwide customers. Our experienced staffs are confident in making your program a success. Moreover, our services are characterized by:
To meet every client’s specific requirements, we also provide antifungal drug discovery services against other pathogens that can also cause human infections, which including but not limited to A. Fumigates, A. Terreus, A. Niger, and A. Nidulans. For more detailed information, please feel free to contact us.
Reference
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