Histone Deacetylase

Experienced scientists at Creative Biolabs have developed antifungal drug discovery services based on multiple technology platforms. The field of antifungal-based drug discovery has rapidly grown up and developed. The explosion of microbiology, proteomics, and bioinformatics provides a number of new targets for the discovery of antifungal drugs. Based on your specific requirements, our experts provide customized drug discovery strategies to identify lead compounds and preclinical candidates.

What is Histone Deacetylases?

Histone deacetylase (HDAC), also known as Lysine deacetylase (KDAC), is a class of enzymes that remove acetyl groups from ε-N-acetyl lysine amino acids on histones, allowing histones to wrap DNA more tightly. HDAC is involved in a range of pathways within the life system, including signal transduction, gap signaling pathways, cell growth, and death, as well as cell cycle regulation and the like. As an important regulatory protein, HDAC can perform a number of post-translational modifications, the most important of which are various modifications of phosphorylation and lysine residues.

Histone Deacetylases as Antifungal Drugs Discovery Targets

On the issue of virulence, the study of the pharmacological inhibition of HDAC found that key virulence factors such as melanin synthesis, phospholipase, and capsular polysaccharide production are affected in a dose-dependent manner. In addition, HDAC also affects morphogenesis (filamentation and mating) and cell cycle changes (resulting in G2/M arrest). Therefore, HDAC is currently considered to be a target for the development of new antifungal drugs, as these enzymes have been described as regulators of key virulence in important pathogenic fungal species. Creative Biolabs is committed to developing HDAC potential new targets for our worldwide customers.

Fig.1 HDACs and morphogenesis in C. albicans. (Garnaud, 2016)

Outsourcing Your Drug Discovery Starts at Creative Biolabs

In today's rapidly changing pharmaceutical industry, drug development requires a higher level of professional technical support from life sciences service providers. Creative Biolabs has a team of professionals who listen carefully to your needs, a team of experts in screening, analysis, and custom testing development to support you before, during and after your experiment. Currently, we provide the following entire pipeline services including:

• Target Identification and Validation: including whole genome sequencing (WGS), computer-aided target identification and validation, structure determination, functional analysis and in vivo target validation.
• Hit Identification: including antifungal compound libraries, virtual screening, fragment-based screening, phenotypic screening, high throughput screening, and drug repurposing.
• Hit to Lead: including hit characterization, developability assessment of biopharmaceutical candidates, molecular engineering and in vitro pharmacodynamics.
• Lead Optimization: including in vitro toxicity test, in vivo PK studies, pharmacology and pharmacodynamics and studies process and scale-up.
• IND-Enabling: including toxicity and safety evaluation, pre-formulation development, formulation development, and human dose prediction.

If you are looking for more details about antifungal drug discovery services, please feel free to contact us or email us. Our drug development services department will gladly meet your drug discovery needs.

Reference

1. Garnaud, C.; et al. Histone Deacetylases and Their Inhibition in Candida Species. Frontiers in Microbiology. 2016, 7(165rv13):1238.

For Research Use Only.