In Vitro Safety Pharmacology Studies on Central Nervous System

With the breadth of in vitro safety pharmacology services and expertise, our clients have successfully launched the safety pharmacology assessments during drug development. Creative Biolabs has established a series of in vitro safety pharmacology assays covering a wide range of disease types. As a global leader in the area of drug development, we are dedicated to offering the most appropriate solutions to facilitate your lead optimization and help you make smarter decisions.

Central Nervous System (CNS) Disease Models

Our scientists have established a full range of CNS in vitro models to facilitate your drug development to treat neurological diseases including but not limited to:

• Epilepsy
• Stroke
• Amyotrophic Lateral Sclerosis (ALS)
• Alzheimer’s Disease
• Parkinson’s Disease
• Human Brain Tumor

We provide a comprehensive set of cell-based models to facilitate in vitro CNS safety pharmacology studies.

• Primary neurons & neuronal cell lines
• Established HeLa cell clone
• Rat primary pituitary cells
• Rat primary cortical neurons
• Multiple cellular models
• Multiple established cell clones
• AtT20/Primary pituitary cells
• Ionotropic and metabotropic receptor pharmacology
• Co-culture of mouse myotubes and primary spinal cord neurons
• HepG2 cell line
• Enzymatic assay
• 3D model

Central Nervous System (CNS) In Vitro Safety Pharmacology Services

According to ICH S7A guidelines, the safety pharmacology effects of the test drug candidates on the CNS should be assessed appropriately. To meet the requirements of IND application, Creative Biolabs offers a variety of CNS safety assessment assays to evaluate the function of motor activity, behavioral changes, sensory/motor reflex responses, etc. With extensive experience over 10 years, our scientists have established many CNS assays (see below table). If you have any specific requirements which can’t be assessed by the listed assays, please let us know and our team will accommodate the properties of your project and tailor the most appropriate assay for you. Once the study is completed, we will provide the reliable and user-friendly data to facilitate your decision-making.

Highlight Features

• Flexible, versatile analytical techniques for in vitro CNS safety pharmacology services;
• The deliverable results include detailed design, protocol, report, and interpretation;
• Seasoned experts and technicians with abundant project experiences;
• Specialized custom services about in vitro CNS safety pharmacology.

Our scientific, technical and regulatory experts provide the right expertise early in the preclinical development process to boost productivity, efficiency and profitability, and help our clients obtain the safest candidates. Creative Biolabs’ unique combination of expertise in CNS and in vitro safety pharmacology makes us an ideal partner to support your drug development. Please contact us to learn how we can be involved in your project.

For Research Use Only.