As a leading CRO company, Creative Biolabs is devoted to helping global clients to explore and identify the potential and well-recognized targets for antifungal drug development. Here we describe the attractive antifungal targets involved in the phospholipid biosynthesis.
Fungi cell membrane is rich in a variety of lipids belonging to the class glycerophospholipids, sphingolipids, and sterols. Glycerophospholipids consist of glyc-erol-3-phosphate that contains two fatty acyl chains along with various substituents like choline, serine, and ethano-lamine. Various phospholipids have been detected including phosphatidic acid, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidylinositol (PI), cardiolipin and sphingolipids such as inositol phosphateceramide, mannosyl-inositolphosphate-ceramide, and mannosyl-diinositolphosphate-ceramide in the cell membrane of Saccharomyces cerevisiae.
Phospholipid biosynthesis pathways in fungi include endogenous and exogenous pathways. In almost all endogenous pathways, all membrane phospholipids are synthesized via a common liponucleotide precursor called CDP-diacylglycerol (CDP-DAG). PS is synthesized via PS synthase by catalyzing the reaction between CDP-DAG and serine, whereas PE and serine are converted to PS by the enzyme PS synthase II in other organisms. Therefore targeting fungal PS synthase would be a promising approach for antifungal drug development. Besides, some key enzymes specific to fungi in phospholipid biosynthesis also become the targets of antifungal drug development, such as PS decarboxylase and PE N-methyl-transferase.
Creative Biolabs has an outstanding professional team and diverse advanced technology platforms to provide customers worldwide with a full range of antifungal drug discovery services including target identification and validation, Hit identification, Hit to lead, Lead optimization, and IND enabling. Our services not only enable you to obtain a final result but also provide a whole-process technical support service so that you can keep abreast of the progress of the project and obtain our technical guidance in a timely manner.
If you are interested in our antifungal drug discovery package services, please do not hesitate to contact us for more details or a detailed quote.
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