Pre-formulation studies are an essential component of drug development process and it provides scientific basis for formulation development. As a part of our pre-formulation development service, Creative Biolabs provides purity determination service by analysis of the DSC melting peak for determining the purity of a material.
It has already been observed that if impurities are present in a material, the melting point will be changed. Less pure compounds will exhibit a broadened melting peak than a pure compound. With the introduction of differential scanning calorimetry (DSC), it has rapidly developed to become a method of quantifying the levels of impurity. DSC is a thermoanalytical technique which measures the amount of energy absorbed or released by a sample when it is heated or cooled, and then providing quantitative and qualitative data on endothermic and exothermic processes.
Figure 1 Introduction of differential scanning calorimetry (DSC)
The principle of using DSC for purity determination is shown in Figure 1. Tested sample is placed in a suitable pan and sits upon a constantan disc with a chromel wafer for measuring the sample temperature. A reference pan sits on a symmetric platform by providing high purity reference sample. Heat flow is measured by comparing the difference in temperature across tested sample and the reference sample.
Creative Biolabs provides precise measurements of heats by DSC and gives sufficient information to support successful purity determinations. The DSC is the simplest analytical method for getting information about the purity and about the crystal form of the sample under investigation. Temperature provided can range from -120°C to 725°C and the temperature is measured with a repeatability of ±0.1°C.
However, not all compounds can be analyzed by DSC. The compounds suitable to be analyzed by DSC for purity scope should meet the conditions below:
Characteristics of Our DSC Platform
For more detailed information, please feel free to contact us or directly sent us an inquiry.
For Research Use Only.