Vaginal candidiasis is a considerable problem among women of childbearing age. About 75% of all women suffer at least one episode of vaginal candidiasis during their lifetime. Because of the urgent need for novel antifungal drugs and the paucity of selective fungal targets, Creative Biolabs offers a comprehensive series of high-quality services to discover new drug candidates for the treatment of vaginal candidiasis.
What is Vaginal Candidiasis?
Vaginal candidiasis, which is also called a vaginal yeast infection, vulvovaginal candidiasis, or candidal vaginitis, is a mucosal infection that affects plenty of otherwise healthy women of childbearing age. It is an opportunistic fungal infection that usually caused by Candida albicans but occasionally be caused by other Candida sp. or yeasts. C. albicans is a commensal organism of the gastrointestinal and reproductive tracts, which causes 85~90% of cases of vaginal candidiasis. A healthy vagina contains bacteria and some yeast cells. Generally, Candida lives in the mouth, throat, gut, as well as the vagina of human bodies, without causing any problems. However, the excessive growth of Candida in the vagina would lead to irritation and result in vaginal candidiasis.
Symptoms of Vaginal Candidiasis
Although most vaginal candidiasis is mild, some patients can develop moderate or severe infections. The symptoms of vaginal candidiasis include:
Diagnosis of Vaginal Candidiasis
Vaginal candidiasis is simple to diagnose. A laboratory examination is usually needed to diagnose vaginal candidiasis since the symptoms are similar to those of other types of vaginal infections. A small sample of vaginal discharge would be collected to be examined under a microscope or sent to a laboratory for a fungal culture. The presence of fungi can also be diagnosed through antigen tests. However, a positive fungal culture does not always imply that Candida is the cause of the symptoms because some women may have Candida in the vagina without having any symptoms.
Treatment of Vaginal Candidiasis
Generally, vaginal candidiasis is treated with antifungal drugs. Antifungal therapy is useful for individual attacks of vaginal candidiasis but does not prevent recurrence, and antifungal drug resistance does not lead to recurrence. For most infections of vaginal candidiasis, the therapeutic method is with intravaginal or oral antifungal drugs. For more severe situations, infections that don't get better, or keep recurring after getting better, other treatments may be needed.
Antifungal Drug Discovery for Invasive Candidiasis at Creative Biolabs
Creative Biolabs is a recognized expert in fungal infection disease and antifungal drug discovery. We can assist you in preclinical drug through a series of assays including:
Our scientists are committed to providing our worldwide client with a comprehensive service package, which includes target identification and validation, Hit identification, Hit to lead, Lead optimization, and IND enabling. In addition to vaginal candidiasis, we also provide drug discovery services against other types of candidiasis as well as Candida spp., which are as follows:
If you are interested in our antifungal drug discovery services, please do not hesitate to contact us for more details.
For Research Use Only.
