Supports
To be your best companion in the fully humanized antibody discovery field, Creative Biolabs is highly specialized in the field of antibody discovery. Based on our non-stop exploration and leading technologies, we have established multiple strategies to raise highly specific, highly affinity antibodies using the transgenic CAMouse™ strains.
Hybridoma
Hybridoma technology has long been a traditional and most widely applied approach for monoclonal antibody generation. As a well-established methodology, hybridoma technology can isolate binders with high binding affinity (low nanomolar range) and native characteristics. Creative Biolabs has tailored numerous high-specificity, high-affinity hybridoma clones with over 90% success rate.
Phage Display
Phage display emerged as a promising approach that can raise a large number of promising antibodies. Incorporated with high-throughput, versatile enriching screening strategies, our scientists have successfully raised binders with 1-10 nM affinity against a variety of targets using phage display.
Native™ Antibody Discovery
This world-leading platform can be used to discover native monoclonal antibodies. Based on innovative B lymphocyte cytometry technology plus antibody gene cloning from single cells, we can analyze and isolate every single cell that interacts with the specific target from the whole B cell repertoire. Hundreds of potential binders can be harvested at one time.
A brief comparison of the three approaches
| Hybridoma | Phage Display | Native™ Antibody Discovery | |
| Candidate Pool of Potential Binders | Relatively small | Large | Large |
| Antibody Enriching Strategy | No | Yes | Yes |
| Developability | Good | Medium | Good |
| Native Paired VH/VL | Yes | No | Yes |
| Discovery Speed | Fast | Medium | Fast |
The PhD-level scientists in Creative Biolabs are more than happy to leverage our experience and technologies to facilitate your specific project. Please feel free to contact us for more information.
Please note: we only produce antibodies for research purposes. Our products and services cannot be used directly on humans.
