Assay Name
In Vitro Activator/Inhibitor Screening Assay
Short Description
Screen for agonists or antagonists of CD27-CD70 signaling in a physiologically relevant cellular context.
Assay Description
Creative Biolabs has developed several I-O function assay based on our stable cell Lines expressed the most popular immune checkpoints. CD27 (Human) Activator/Inhibitor Screening Assay, Jurkat (CD27 & NFAT-Luc)-based is applied to screen for agonists or antagonists of CD27-CD70 signaling in a physiologically relevant cellular context. The assay will be customized according to the client's specific requirements. Please contact our scientists to discuss more details.
Assay Alternative Names
In Vitro Activator/Inhibitor Screening Assay; Activator/Inhibitor Screening Assay
Assay Reporter
NFAT-Luciferase Reporter
Assay Type
Activator/Inhibitor Screening Assay
Assay MOA
Creative Biolabs has developed several immune checkpoint stable cell Lines expressing the most popular immune checkpoints to accelerate clients' immunotherapy discovery and clinical translation. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NF-kB response elements with constitutive expression of human CD27 (also known as Tumor Necrosis Factor Receptor Superfamily Member 7, TNFRSF7, and T14, Genbank Accession #BC012160) Which can be used in binding assays and functional assay.