Short Decsription
Creative Biolabs offers CHO-K1-Tg(Human beta1 Receptor) Division-Arrested Cell which beta1 receptor stably expressed in CHO-K1 cells.
Description
CHO-K1-Tg(Human beta1 Receptor) Division-Arrested Cell was engineered to express the receptor human beta1 (AF169007.1). This cell line can be used to study beta1 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.
Features
Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.
Applications
beta1 receptor function, signaling pathways, and potential therapeutic interventions.
Protein Target
GPCR
Receptor Name
beta1
Receptor Family
Adrenergic
Species
Human
Parental Cell Line
CHO-K1
Transfection
Expression vector containing full-length human ADRB1 cDNA (GenBank Accession Number AF169007.1) with FLAG tag sequence at N-terminus
Gene
AF169007.1
Background
Norepinephrine is implicated in a wide range of physiological processes through activation of nine different G-protein-coupled receptors (α1a, α1b, α1d, α2a, α2b, α2c, β1, β2, β3). The human β1-adrenergic receptor is a 477-amino acid protein found in various heart and brain tissues. β1 has an important role in the contractile action of valves in cardiac and digestive systems.

For Research Use Only | Not For Clinical Use

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