CellOnco™ HEK293T-Tg(Human 5-HT2B Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM689)

Creative Biolabs offers HEK293T-Tg(Human 5-HT2B Receptor) Division-Arrested Cell which 5-HT2B receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human 5-HT2B Receptor) Division-Arrested Cell was engineered to express the receptor human 5-HT2B (NM_000867). This cell line can be used to study 5-HT2B receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

5-HT2B receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

5-HT2B

Serotonin

Human

HEK293T

Full-length Human HTR2B cDNA (GenBank Accession Number NM_000867) with FLAG-tag sequence at the N-terminus

NM_000867

5-HT2B (5-hydroxytryptamine receptor 2B) is a receptor for serotonin. It is expressed in many peripheral and central nervous system tissues, including stomach fundus, liver kidney, muscle, intestine and brain. 5-HT2B receptors are responsible for many cardiovascular and central nervous system functions, such as blood vessel contraction, platelet shape changes, neuronal sensitization to tactile stimuli, and mediation of the hallucinogenic effects of phenylisopropylamin hallucinogens. It has also been shown to be required for heart development.