CellOnco™ HEK293T-Tg(Human 5-HT7 Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM695)

Creative Biolabs offers HEK293T-Tg(Human 5-HT7 Receptor) Division-Arrested Cell which 5-HT7 receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human 5-HT7 Receptor) Division-Arrested Cell was engineered to express the receptor human 5-HT7 (NM_019860.2). This cell line can be used to study 5-HT7 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

5-HT7 receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

5-HT7

Serotonin

Human

HEK293T

Expression vector containing full-length human HTR7 cDNA (GenBank accession number NM_019860.2) with FLAG tag sequence at N-terminus

NM_019860.2

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin. The 5-HT7 receptor is expressed in a variety of tissues, particularly in the brain, the gastrointestinal tract, and various blood vessels. The 5-HT7 receptor plays a role in smooth muscle relaxation within the vasculature and in the gastrointestinal tract, and is involved in thermoregulation, circadian rhythm, learning and memory, and sleep. This receptor is also involved in mood regulation, suggesting that it may be a useful target in the treatment of depression.