CellOnco™ HEK293T-Tg(Human C3AR1 Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM515)

Creative Biolabs offers HEK293T-Tg(Human C3AR1 Receptor) Division-Arrested Cell which C3AR1 receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human C3AR1 Receptor) Division-Arrested Cell was engineered to express the receptor human C3AR1 (NM_004054.2). This cell line can be used to study C3AR1 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

C3AR1 receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

C3AR1

Anaphylatoxin

Human

HEK293T

Expression vector containing full-length human C3AR1 cDNA (GenBank Accession Number NM_004054.2) with FLAG tag sequence at N-terminus

NM_004054.2

C3a receptor (C3a anaphylatoxin chemotactic receptor) is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. The receptor is widely expressed in many hematopoietic cell lines, throughout the CNS and other tissues, and the expression level in glial cells increases during CNS inflammation. It stimulates chemotaxis, granule enzyme release and superoxide anion production, mediates the pathogenesis of demyelinating disease by directly or indirectly chemoattracting encephalitogenic cells to the CNS. Administration of small molecule inhibitors of C3a receptor inhibits airway responses.