CellOnco™ HEK293T-Tg(Human CaSR Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM526)

Creative Biolabs offers HEK293T-Tg(Human CaSR Receptor) Division-Arrested Cell which CaSR receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human CaSR Receptor) Division-Arrested Cell was engineered to express the receptor human CaSR (NM_000388). This cell line can be used to study CaSR receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

CaSR receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

CaSR

Calcium-Sensing

Human

HEK293T

Expression vector containing full-length human CASR cDNA (GenBank accession number NM_000388) with FLAG tag sequence at N-terminus

NM_000388

CASR is a calcium-sensing receptor and plays an important role in regulating PTH secretion. It is expressed in many different tissues, such as parathyroid cells, pituitary cells, kidney, fibroblasts, keratinocytes and human colon epithelial cells. CASR is a potential therapeutic target for the treatment of many diseases, including hyperparathyroidism and osteoporosis. Mutations in the CASR gene can result in gain or loss of receptor function. Familial Hypocalciuric Hypercalcemia (FHH) and Neonatal Severe Primary Hyperparathyroidism (NSHPT) have been associated with loss of CASR function, while Autosomal Dominant Hypocalcemia (ADH) and Bartter syndrome type V have been associated with gain of CASR function.