CellOnco™ HEK293T-Tg(Human EP1 Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM667)

Creative Biolabs offers HEK293T-Tg(Human EP1 Receptor) Division-Arrested Cell which EP1 receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human EP1 Receptor) Division-Arrested Cell was engineered to express the receptor human EP1 (NM_000955.2). This cell line can be used to study EP1 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

EP1 receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

EP1

Prostanoid

Human

HEK293T

Expression vector containing full-length human PTGER1 cDNA (GenBank accession number NM_000955.2) with FLAG tag sequence at N-terminus

NM_000955.2

EP1 receptor (or PTGER1) is a receptor or prostaglandin E2 (PGE2). The receptor may play a role in the smooth muscle contractile response to PGE2 in various tissues. EP1 receptor transactivates EGFR thus activating Akt, while activation of EGFR by its cognate ligand EGF increased COX-2 expression and PGE2 production. This crosstalk between EP1 and EGFR signaling synergistically promotes cancer cell growth and invasion. Some EP1- specific antagonists inhibit osteoclast formation induced by RANKL from the early stage of osteoclastogenesis.