CellOnco™ HEK293T-Tg(Human FP Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM671)

Creative Biolabs offers HEK293T-Tg(Human FP Receptor) Division-Arrested Cell which FP receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human FP Receptor) Division-Arrested Cell was engineered to express the receptor human FP (NM_000959). This cell line can be used to study FP receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

FP receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

FP

Prostanoid

Human

HEK293T

Expression vector containing full-length human PTGFR cDNA (GenBank accession number NM_000959) with FLAG tag sequence at N-terminus

NM_000959

Prostaglandin F (2-alpha) is involved in a number of physiologic processes. It serves as a potent luteolytic agent in many species, has been implicated as a modulator of intraocular pressure, smooth muscle contraction in the uterus and elsewhere. Its effects on cells are mediated through specific interaction with the prostaglandin F receptor (FP or PTGFR). Knockout mice lacking the FP receptor are unable to deliver normal fetuses at term due to a lack of response to oxytocin. The mice also failed to show the decline in serum progesterone expected to precede parturition.