CellOnco™ HEK293T-Tg(Human FPR1 Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM631)

Creative Biolabs offers HEK293T-Tg(Human FPR1 Receptor) Division-Arrested Cell which FPR1 receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human FPR1 Receptor) Division-Arrested Cell was engineered to express the receptor human FPR1 (NM_002029.3). This cell line can be used to study FPR1 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

FPR1 receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

FPR1

N-formylpeptide

Human

HEK293T

Expression vector containing full-length human FPR1 cDNA (GenBank Accession Number NM_002029.3) with FLAG tag sequence at N-terminus.

NM_002029.3

The gene FPR1 encodes the formylpeptide receptor (FPR), which is a G-protein-coupled receptor that mediates chemotaxis of phagocytic leukocytes induced by bacterial peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP). Agonist binding to FPR in phagocytic leukocytes leads to the activation of phosphatidylinositol 3-kinase (PI3K), mitogen-activated protein kinases (MAPKs), and the transcription factor nuclear factor (NF)-kB via heterotrimeric Gαi proteins. FPR is involved in host defense against bacterial infection and in the clearance of damaged cells. Recently a large number of non-formylated peptide ligands for FPR have now been identified. Some of the new ligands (e.g. Ac1-26 from annexin) are endogenous in origin, and some come from pathogens that are associated with human diseases such as HIV, which have suggested novel roles for this receptor in the regulation of acute and chronic inflammation as well as host responses during HIV-1 infection.