CellOnco™ HEK293T-Tg(Human Gαqi5//Human mGlu8 Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM625)

Creative Biolabs offers HEK293T-Tg(Human Gαqi5//Human mGlu8 Receptor) Division-Arrested Cell which mGlu8 receptor stably expressed in HEK293T cells which overexpress Gαqi5.

HEK293T-Tg(Human Gαqi5//Human mGlu8 Receptor) Division-Arrested Cell was engineered to express the receptor human mGlu8 (NM_000845.1). This cell line can be used to study mGlu8 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

mGlu8 receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

mGlu8

Metabotropic Glutamate

Human

HEK293T Gαqi5

Expression vector containing full-length human mGluR8 cDNA (GenBank Accession Number NM_000845.1) with FLAG tag sequence at N-terminus.

NM_000845.1

The metabotropic glutamate receptors (mGluRs) have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group II and group III mGluRs are linked to the inhibition of the cyclic AMP cascade, but differ in agonist selectivity. Group III agonists include L-2-amino-4-phosphonobutyrate (L-AP4) and L-serine-O- phosphate. The human mGluR8 protein shares 67 to 70% sequence similarity with mGluR4 and mGluR7 and 99% amino acid identity with mouse mGluR8.