CellOnco™ HEK293T-Tg(Human mGlu2 Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM616)

Creative Biolabs offers HEK293T-Tg(Human mGlu2 Receptor) Division-Arrested Cell which mGlu2 receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human mGlu2 Receptor) Division-Arrested Cell was engineered to express the receptor human mGlu2 . This cell line can be used to study mGlu2 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

mGlu2 receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

mGlu2

Metabotropic Glutamate

Human

HEK293T

Expression vector containing full-length human GRM2 cDNA with FLAG tag sequence at N- terminus

The neurotransmitter L-glutamate interacts with both ionotropic and metabotropic receptors. The metabotropic glutamate receptors (mGluRs), which are G protein-coupled receptors, have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group II and group III mGluRs are linked to the inhibition of the cyclic AMP cascade, but differ in their agonist selectivity. The mGluR2 is a member of group II metabotropic glutamate receptors.