CellOnco™ HEK293T-Tg(Human P2Y2 Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM678)

Creative Biolabs offers HEK293T-Tg(Human P2Y2 Receptor) Division-Arrested Cell which P2Y2 receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human P2Y2 Receptor) Division-Arrested Cell was engineered to express the receptor human P2Y2 (NM_002564). This cell line can be used to study P2Y2 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

P2Y2 receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

P2Y2

Purinergic

Human

HEK293T

Expression vector containing full-length human P2Y2 cDNA (GenBank Accession Number NM_002564) with FLAG tag sequence at N-terminus

NM_002564

The P2Y2 receptor was the first of this family of receptors that can be fully activated by both ATP and UTP. P2Y2 receptors are present on all of the body's mucosal surfaces, including the lungs, eyes, upper airways, mouth, vaginal tract and gastrointestinal tract. P2Y2 receptors have also been found on non-mucosal surfaces, such as the retinal pigment epithelium. Activation of P2Y2 has been shown to stimulate mucosal hydration and mucociliary clearance in the lungs and upper airways and induce secretion of therapeutically significant amounts of fluid and tear components to the ocular surface. Thus, P2Y2 receptors are therapeutic targets for treating serious disorders including cystic fibrosis, a fatal genetic disease, retinal detachment as well as dry eye disease.