Short Decsription
Creative Biolabs offers HEK293T-Tg(Mouse A2A Receptor) Division-Arrested Cell which A2A receptor stably expressed in HEK293T cells.
Description
HEK293T-Tg(Mouse A2A Receptor) Division-Arrested Cell was engineered to express the receptor mouse A2A (NM_009630.3). This cell line can be used to study A2A receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.
Features
Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.
Applications
A2A receptor function, signaling pathways, and potential therapeutic interventions.
Parental Cell Line
HEK293T
Transfection
Full-length Mouse ADORA2A cDNA (GenBank Accession Number NM_009630.3) with FLAG-tag sequence at the N-terminus
Background
Adenosine regulates the function of the innate and adaptive immune systems through targeting virtually every cell type that is involved in orchestrating an immune/inflammatory response. Of the four adenosine receptors (A1, A2A, A2B, A3), A2A receptor is the primary anti-inflammatory effectors of extracellular adenosine. A2A receptor predominant expresses in monocytes/macrophages, dendritic cells, mast cells, neutrophils, endothelial cells, eosinophils, epithelial cells, as well as lymphocytes, NK cells, and NKT cells. Its activation inhibits early and late events occurring during an immune response. A2A receptor also participates in tissue remodeling and reparation. A2A receptor has been shown to impact the course of a wide spectrum of ischemic, autoimmune, infectious, and allergic diseases, and has regulatory roles in immune/inflammatory diseases of various organs, including heart, lung, gut, liver, kidney, joints, and brain. Recently, A2A receptor has become a particularly attractive target to manage psychiatric disorders.
Datasheet