Short Decsription
LAL chromogenic endotoxin quantitation kit uses LAL to detect the content of endotoxins in protein, peptide, or antibody samples.
Description
LAL chromogenic endotoxin quantitation kit uses LAL to detect the content of endotoxins in protein, peptide, or antibody samples.
Features
Reagent reacts with endotoxin over a wide range of its concentrations; Reduces the chance of interfering factors due to high sensitivity.
Applications
Endotoxin detection
Molecular Mechanism of Action
LAL test relys on factor C coagulation cascade found in horseshoe crabs' blood. The combination of endotoxin and zymogen factor C initiate the protease cascade. Next, the activated factor C goes onto activate factor B, which converts the proclotting enzyme to the clotting enzyme. Lastly, two peptide bonds in coagulogen are catalytically cleaved to form coagulin gel.
Detection Method
Chromogenic
Method Type
Lyophilized amebocyte lysate (LAL)
Datasheet