Hbl-2 In Vitro ATP Assay (Cell Viability) (CAT#: ITS-0123-YF3579)

Hbl-2

Human

The HBL-2 cell line is derived from an AIDS-SNCCL (AIDS-associated small non-cleaved cell lymphoma) patient. After immunophenotypic and molecular genetic analysis, the HBL-2 was established from the original tumor clones. The HBL-2 cell line presents surface immunoglobulin and B-cell restricted markers as well as a phenotype consistent with SNCCL; the cell line also displays clonal immunoglobulin gene rearrangement. The HBL-2 cell line is considered useful as a biological model to study AIDS-associated non-Hodgkin lymphomagenesis (AIDS-NHL) and the impacts of biological, immunological, and viral factors involved.

Mantle Cell Lymphoma; MCL

Oncology

In Vitro ATP Assay (Cell Viability)

Adenosine triphosphate (ATP) assay is another widely used cell viability assay. When the cancer cells undergo apoptosis or necrosis upon treatment with a compound, cellular ATP content decreases and it can be quantified by colorimetric, fluorometric or luminometric way. The latest bioluminescence assays measure cellular ATP content using the enzyme luciferase which is more sensitive and reproducible when determining cell viability compared to conventional assays.

Adenosine Triphosphate Assay

Cell Viability/Cytotoxicity and Antiproliferative Assays

Uncontrolled proliferation is one of the main features of cancer cells. Cell-based in vitro assays are employed to determine whether test molecules possess direct cytotoxic/antiproliferative effects in cancer cells.

Cell Viability Assay

Cell-based Viability Assays Based on Cellular Enzymes and Proteins