Alternative Name
Cluster Of Differentiation 226 (CD226)
Synonyms
CD226; cd226; zgc:158817; BC051526; DNAM-1; DNAM1; Pta1; TLiSA1; PTA1; CD226 molecule; CD226 antigen; CD226; cd226; Cd226
Background
CD226 involves in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.
Pathways
Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints