Alternative Name
Tumor necrosis factor receptor superfamily member 14
Synonyms
ATAR; CD270; HVEA; HVEM; LIGHTR; TR2; Atar; HveA; Hvem; Tnfrs14; TNF receptor superfamily member 14; tumor necrosis factor receptor superfamily; member 14 (herpesvirus entry mediator); Tnfrsf14; TNFRSF14
Background
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) is the receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
Pathways
Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints