Description
Creative Biolabs has developed several immune checkpoint stable cell Lines expressing the most popular immune checkpoints to accelerate clients' immunotherapy discovery and clinical translation. Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #NM_005018). Which can be used in binding assays and functional assay.
Features
Stable cell lines for increased reliability and reproducibility;
Protein expression at the cell surface validated by FACS or WB;
Applications
Screen for activators or inhibitors of PD-1 signaling in a cellular context.
Characterize the biological activity of PD-1 and its interactions with ligands.
Organism
Human
Strain Name
Jurkat
Common Name
PD-1
Background
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.

For Research Use Only | Not For Clinical Use

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