Short Decsription
Creative Biolabs offers Jurkat-B2M KO cell line which B2M gene was knocked out in Jurkat cells.
Description
Jurkat-B2M KO cell line is a type of Jurkat cell line that has been genetically modified to lack the expression of beta-2 microglobulin (B2M). B2M is a protein that is required for the proper function of major histocompatibility complex (MHC) class I molecules, which are important for antigen presentation to T cells. By knocking out the expression of B2M, the Jurkat-B2M KO cell line can be used to study the role of B2M in antigen presentation and T cell activation. This cell line can be useful for investigating the immune response to viral infections, cancer, and autoimmune diseases, as well as for drug development and testing.
Features
Loss of gene function;
Stability and Specificity;
Reliability and reproducibility;
Applications
Functional assay
Protein Target
B2M
Species
Human
Parental Cell Line
Jurkat
Background
The B2M gene, also known as beta-2 microglobulin, is a gene that provides instructions for making a protein that is found on the surface of all cells in the body. This protein is important for the immune system, as it plays a role in presenting antigens to immune cells to help the body identify foreign invaders, such as bacteria or viruses. Mutations in the B2M gene can lead to various health conditions, including certain types of cancer and autoimmune disorders.

For Research Use Only | Not For Clinical Use

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