Product Overview
GANT 58 is a GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). It inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.
Applications
Cell Culture and Assay
Size
10 mg
Chemical Name
2,3,4,5-Tetra(4-pyridyl)thiophene
Cell Type
Cancer Cells and Cell Lines, Prostate Cells
Pathway
Hedgehog
Target
GLI
Subtype
GLI Inhibitor
Area of Interest
Immunology
Limitation
Restrictions for research use only. Intended for use by laboratory professionals.

For Research Use Only | Not For Clinical Use

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