Product Overview
GANT 58 is a GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). It inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.
Applications
Cell Culture and Assay
Chemical Name
2,3,4,5-Tetra(4-pyridyl)thiophene
Cell Type
Cancer Cells and Cell Lines, Prostate Cells
Area of Interest
Immunology
Limitation
Restrictions for research use only. Intended for use by laboratory professionals.