PharmaOnco™ CHO-Tg(Human FcGR2B//TCR Activator) Stable Cell Line, Single Clone (CAT#: ITS-0822-HMM206)

Creative Biolabs offers CHO-Tg(Human FcGR2B//TCR Activator) stable cell line which the TCR Activator and FcGR2B gene stably expressed in CHO cells.

CHO-Tg(Human FcGR2B//TCR Activator) stable cell line is a specialized cell line that has been genetically engineered to express both the human Fc gamma receptor 2B (FcGR2B) and a T cell receptor (TCR) activator. The FcGR2B receptor enhances TCR signaling and promotes T cell activation when bound to the appropriate ligand, leading to increased immune response activation. This cell line has been extensively characterized and validated for its ability to efficiently activate T cells and enhance immune responses in various experimental settings. It can be used for a wide range of applications, including studying T cell activation mechanisms, immune response modulation, and drug development targeting TCR signaling pathways.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

TCR Activator/FcGR2B

Human

CHO

TCR (T cell receptor) activators are molecules or compounds that stimulate the activity of T cells in the immune system. T cells play a crucial role in the body's immune response by identifying and attacking foreign invaders such as viruses, bacteria, and cancer cells.
The FcGR2B gene encodes for the Fc gamma receptor 2B, a cell surface receptor that is expressed on the surface of various immune cells, such as B cells, monocytes, and dendritic cells. This receptor plays a role in regulating immune responses by interacting with immunoglobulin G (IgG) antibodies and modulating signaling pathways involved in inflammation, antibody production, and phagocytosis. Mutations or dysregulation of the FcGR2B gene can lead to immune disorders, autoimmune diseases, and susceptibility to infections. Studies have also suggested that the FcGR2B gene may be a potential target for immunotherapy in certain diseases.