PharmaOnco™ HEK293-Tg(Human SIRP-α) Stable Cell Line, Single Clone (CAT#: ITS-0822-HMM200)

Creative Biolabs offers HEK293-Tg(Human SIRP-α) stable cell line which the SIRP-α gene stably expressed in HEK293 cells.

The HEK293-Tg(Human SIRP-α) stable cell line is a genetically modified cell line derived from HEK293 cells that expresses the human SIRP-α protein. SIRP-α, or signal regulatory protein alpha, is a cell surface protein that plays a critical role in regulating immune responses, particularly in the context of immune cell activation and inhibition. The stable expression of human SIRP-α in the HEK293 cell line allows for the study of the protein's function and signaling pathways in a controlled laboratory setting. This cell line can be used in various research applications, such as studying immune cell interactions, investigating immune checkpoint pathways, and developing novel therapeutics targeting the SIRP-α protein.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

SIRP-α

Human

HEK293

GenBank Accession #NM_080792

The SIRP-alpha (signal regulatory protein alpha) gene encodes a cell surface protein that plays a role in regulating immune responses. It is primarily expressed on myeloid cells and functions as a negative regulator of phagocytosis and inflammation. SIRP-alpha binds to CD47, a widely expressed cell surface protein, which sends a "do not eat me" signal to phagocytic cells. This interaction helps prevent the unnecessary phagocytosis of healthy cells and tissues. Abnormalities in the SIRP-alpha gene have been associated with various diseases, including cancer and autoimmune disorders. Research is ongoing to better understand the role of SIRP-alpha in immune regulation and develop potential therapeutic interventions targeting this pathway.