PharmaOnco™ HEK293-Tg(Human TLR8)-NF-κB Luc Reporter Cell Line, Single Clone (CAT#: ITS-0822-HMM215)

Creative Biolabs offers HEK293-Tg(Human TLR8)-NF-κB Luc reporter cell line which the TLR8 gene stably expressed in NF-κB Luc reporter HEK293 cells.

The HEK293-Tg(Human TLR8)-NF-κB Luc reporter cell line is a cell line derived from HEK293 cells that has been engineered to express human Toll-like receptor 8 (TLR8) and a luciferase reporter gene driven by the NF-κB promoter. TLR8 is a pattern recognition receptor that recognizes single-stranded RNA and activates signaling pathways that lead to the activation of the transcription factor NF-κB.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

TLR8

Human

HEK293

GenBank Accession No. NM_017442

TLR8 (Toll-like receptor 8) is a gene that encodes a protein involved in the immune response to bacterial and viral infections. TLR8 is a member of the Toll-like receptor family, which recognizes pathogen-associated molecular patterns (PAMPs) and triggers the release of inflammatory cytokines. TLR8 is primarily expressed in immune cells such as monocytes, macrophages, and dendritic cells. Mutations in the TLR8 gene have been associated with susceptibility to certain infections and autoimmune diseases. Research on TLR8 continues to uncover its role in the immune system and its potential as a target for therapeutic interventions.