PharmaOnco™ HEK293T-Tg(Human NK1 Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM701)

Creative Biolabs offers HEK293T-Tg(Human NK1 Receptor) Division-Arrested Cell which NK1 receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human NK1 Receptor) Division-Arrested Cell was engineered to express the receptor human NK1 (NM_001058.2). This cell line can be used to study NK1 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

NK1 receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

NK1

Tachykinin

Human

HEK293T

Expression vector containing full-length human TACR1 cDNA (GenBank Accession Number NM_001058.2) with FLAG tag sequence at N-terminus

NM_001058.2

NK1 (or tachykinin receptor TACR1) is a selective receptor for substance P with relatively higher affinity for neurokinin A compared to neurokinin B (100- and 500-fold lower). Neurons in lamina I of the spinal dorsal horn express the NK1 receptor for substance P and mediate hyperalgesia, an enhanced sensitivity to painful stimuli. Although substance P does not mediate the signaling of acute pain or hyperalgesia, it is essential for the full development of stress-induced analgesia and for an aggressive response to territorial challenge. It is also suggested that substance P is important for orchestrating the response of the animal to major stressors such as pain, injury or invasion of territory. Modulation of substance P activity offers a radical new approach to the management of depression, anxiety and stress. The substance P receptor is highly expressed in areas of the brain that are implicated in these behaviors.