PharmaOnco™ Jurkat-NFAT Luc Reporter Cell Line, Single Clone (CAT#: ITS-0822-HMM185)

Creative Biolabs offers Jurkat-NFAT Luc reporter cell line which has been engineered to express a luciferase reporter gene under the control of the NFAT pathway.

The Jurkat-NFAT Luc reporter cell line is a genetically modified cell line derived from Jurkat cells, a human T lymphocyte cell line. These cells have been engineered to express a luciferase reporter gene under the control of the nuclear factor of activated T cells (NFAT) pathway. The NFAT pathway is a crucial signaling pathway in T cells that plays a role in their activation and differentiation. When the NFAT pathway is triggered, NFAT translocates to the nucleus and activates the transcription of target genes, including the luciferase gene in the Jurkat-NFAT Luc reporter cell line. This cell line is widely used in immunology and drug discovery research to study T cell signaling and screen for potential immunomodulatory compounds.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

Jurkat

The NFAT Luc Reporter is a molecular reporter system used in cell biology to monitor the activity of the transcription factor NFAT (nuclear factor of activated T cells). NFAT is a key regulator of immune and inflammatory responses, as well as other cellular processes. The NFAT Luc Reporter consists of a gene encoding the luciferase enzyme under the control of NFAT-responsive elements. When NFAT is activated and translocates to the nucleus, it binds to these elements and induces the expression of luciferase. This results in the production of light (luminescence) that can be easily detected and quantified using a luminometer or other imaging systems.