PharmaOnco™ Jurkat-Tg(Human LAG3)-IL-2 Luc Reporter Cell Line, Single Clone (CAT#: ITS-0822-HMM176)

Creative Biolabs offers Jurkat-Tg(Human LAG3)-IL-2 Luc reporter cell line which the LAG3 gene stably expressed in IL-2 Luc reporter Jurkat cells.

The Jurkat-Tg(Human LAG3)-IL-2 Luc reporter cell line is a genetically modified cell line derived from the Jurkat cell line, a widely used human T cell lymphoma line. This specific cell line has been engineered to express a luciferase reporter gene under the control of the IL-2 promoter, allowing for the monitoring of IL-2 gene expression. Additionally, these cells also overexpress the human Lymphocyte-activation gene 3 (LAG3) protein, which is an immune checkpoint receptor that plays a role in regulating T cell function and immune responses.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

LAG3

Human

Jurkat

GenBank Accession # NM_002286

The Lymphocyte-activation gene 3 (LAG3) is a protein that plays a role in regulating the immune response. It is a cell surface molecule that is expressed on activated T cells, regulatory T cells, and natural killer (NK) cells. LAG3 acts as an immune checkpoint molecule, similar to other checkpoint proteins like PD-1 and CTLA-4, and plays a role in regulating the activation and function of T cells. Binding of LAG3 to its ligands, such as MHC class II molecules, leads to inhibition of T cell proliferation and cytokine production, as well as promoting immune tolerance. Research has suggested that LAG3 may be a potential target for cancer immunotherapy, as blocking LAG3 can enhance anti-tumor immune responses. Studies are ongoing to investigate the potential of targeting LAG3 in cancer treatment.