Assay Name
In Vitro Molecular Biology Assay (Angiogenesis)
Short Description
J82-cell based In Vitro Molecular Biology Assay (Angiogenesis)
Assay Description
Direct detection methods of factors effecting angiogenesis mainly include real-time PCR, western blotting and enzyme-linked immunosorbent assay (ELISA). JAG1, PECAM1, ANGPTL3, MMP2, MMP9, HAND2, TGFA, LAMA5, IL1B, FIGF, TIMP3, ANGPT1, LECT1, EREG and ANPEP are the key genes reported to control angiogenesis.
Assay Type
Angiogenesis Monitoring Assays
Assay Type Details
Local and regional metastasis is a life-threatening condition in cancer, which is hard to control with the available cancer treatment options. In metastasis, cancer cells move away from primary tumors and travel through the blood and lymphatic system and form new tumors on other parts. A vascular
network growth is important for cancer metastasis. Angiogenesis is a process that is known as the formation of new blood vessels with the help of existing blood vessels and angiogenesis has been reported to play a major role in cancer growth and metastasis. Tumors can send chemical signals to nearby normal tissues to stimulate angiogenesis. New blood vessels can feed growing tumors with nutrients and oxygen, allowing cancer cells to spread (metastasis).
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