Short Decsription
The limulus PS single test is designed to overcome any product interference by adsorbing potential endotoxin in samples while washing away the inhibitory components.
Description
The limulus PS single test is designed to overcome any product interference by adsorbing potential endotoxin in samples while washing away the inhibitory components.
Features
Endotoxin-specific reagent avoids false positive results from glucans; This kit is in single test configuration to avoid contamination; Allows endotoxin-specific measurement in samples.
Applications
Endotoxin detection
Molecular Mechanism of Action
LAL test relys on factor C coagulation cascade found in horseshoe crabs' blood. The combination of endotoxin and zymogen factor C initiate the protease cascade. Next, the activated factor C goes onto activate factor B, which converts the proclotting enzyme to the clotting enzyme. Lastly, two peptide bonds in coagulogen are catalytically cleaved to form coagulin gel.
Method Type
Lyophilized amebocyte lysate (LAL)
Datasheet