Assay Name
In Vitro 8-OH-dG Assay (Oxidative Stress)
Short Description
LN-827-cell based In Vitro 8-OH-dG Assay (Oxidative Stress)
Assay Description
8-Hydroxy-2-deoxyguanosine (8-OH-dG) is another critical biomarker for oxidative stress. It is one of the major products generated in oxidative DNA damage by ROS. DNA oxidative damage ELISA kits are available to assess 8-OH-dG levels as an oxidative stress marker.
Assay Alternative Names
8-Hydroxy-2-deoxyguanosine Assay
Assay Type
Oxidative Stress Assays
Assay Type Details
Disturbance between the production of reactive oxygen species (ROS), free radicals and antioxidant mechanisms is defined as the oxidative stress, or more precisely, it is an imbalance between the oxidant and antioxidant state in cells. This imbalance can cause harmful effects to cells and biomolecules, which ultimately causes adverse effects in the whole organism. Oxidative imbalance can target important proteinsand lipids in cells, which can increase the risk of developing a cancer. On the other hand, increased ROS production in cancer cells by certain cancer drugs can also arrest cancer cell cycle and cause senescence and apoptosis through oxidative stress.
Assay Subtype
Markers Thiobarbituric Acid Reactive Substances