Assay Name
In Vitro TRAP Assay (Senescence)
Short Description
NALM6-cell based In Vitro TRAP Assay (Senescence)
Assay Description
The telomerase repeated amplification protocol (TRAP) assay is one of the common PCR-based assays used to detect telomerase activity in cells.
Assay Alternative Names
Telomerase Repeated Amplification Protocol Assay
Assay Type
Cellular Senescence in Cancer Assays
Assay Type Details
Cell senescence is described as an irreversible physiological event of cell growth arrest, which is known to be caused by alterations of telomeres, oxidative stress, DNA damage and some oncogenes. Inhibition of the program of senescence is one of the main features of tumor cells and it has been reported that cancer cells can be induced to undergo senescence by chemo- and radiotherapies and genetic alterations. Telomeres help to prevent uncontrolled cell proliferation and the absence of telomeres results in aneuploidy and cell death.