Short Decsription
This IHC kit offers a complete solution for APOL1 staining, providing all necessary reagents in a ready-to-use format, along with a simplified protocol and optimized reagents for efficient and reliable results.
Description
Human apolipoprotein L1 (APOL1) is a minor component of plasma high-density lipoprotein (HDL) particles and interacts with apolipoprotein A1 (ApoA1). The ApoL protein family is primarily involved in lipid transport and metabolism. APOL1 plays a role in innate immunity against Trypanosoma parasites by lysing the parasite upon activation, thereby protecting humans from infection. Genetic variants of APOL1, common in individuals of African ancestry, are linked to chronic kidney diseases such as focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN), and hypertensive nephropathy. APOL1 shares structural and functional similarities with Bcl-2 family proteins and may be involved in apoptosis and autophagy. Notably, APOL1 is found only in humans and a few other primates; it is absent in mice.
Features
Ready to use
High Sensitivity Streptavidin (HSS) increases detection sensitivity
Suitable for tissue sections & cytospin preparations
Pre-diluted reagents minimize hands-on time
Optimizes mouse, rabbit, rat, goat, or sheep IgG primary antibody staining
Analytical Method
Immunohistochemistry
Datasheet