Short Decsription
Achieve sensitive and specific AXIN2 staining with this IHC kit, which offers a complete solution with carefully formulated reagents for optimal performance and accurate results.
Description
Axis inhibition protein 2 (AXIN2), also known as Coductin or Axil, is a multidomain scaffold protein that negatively regulates Wnt signaling. AXIN2 can directly interact with beta-catenin and GSK3B. AXIN2 has several phosphorylation sites and can undergo poly(ADP-ribosyl)ation by tankyrase TNKS and TNKS2. Poly(ADP-ribosyl)lated AXIN2 is then ubiquitinated by RNF146, leading to its degradation and activation of Wnt signaling. AXIN2 is localized in the cytoplasm, and mutations in AXIN2 are involved in colorectal cancer.
Features
Ready to use
High Sensitivity Streptavidin (HSS) increases detection sensitivity
Suitable for tissue sections & cytospin preparations
Pre-diluted reagents minimize hands-on time
Optimizes mouse, rabbit, rat, goat, or sheep IgG primary antibody staining
Analytical Method
Immunohistochemistry
Datasheet